genetic variability 101 human 88 Article 74 Humans 69 genetics 60 female 56 controlled study 55 male 55 adult 46 Male 40 Female 38 single nucleotide polymorphism 38 major clinical study 36 genotype 35 gene frequency 28 genetic association 28 gene 27 middle aged 23 Adult 22 Polymorphism, Single Nucleotide 22 genetic predisposition 22 nonhuman 22 Genetic Predisposition to Disease 21 Middle Aged 21 article 21 phenotype 20 allele 19 case control study 16 genome-wide association study 16 Case-Control Studies 15